Our friends from The WinVista Club have recently released a nice little tool called Ultimate Windows Tweaker. As you can imagine, the tool allows you to tweak lots of aspects in Windows Vista. For a complete list of available tweaks (over 130 in total), check out the tweaks page.
As you can see in the screenshot below, the interface is simple and straightforward. You can easily go through all the available tweaks and enable the ones you want to with a single click.
If you want to try it out, go to the download page.
TIP: While looking on the Support and Feedback Thread, I’ve noticed that there are a few bugs that need to be ironed out. Nothing major though. However, just to be on the safe side until new and improved versions are released, make sure you create a System Restore point before using the tool.